Article
Phenotype and mRNA expression of syncytiotrophoblast microparticles isolated from human placenta.
Annals of the New York Academy of Sciences - 1 Aug 2008
Kumpel Belinda, King May-Jean, Sooranna Suren, Jackson Dave, Eastlake Jane, Cheng Rong, Johnson Mark
Abstract excerpt
Fetal and neonatal alloimmune thromboctyopenia due to maternal human platelet antigen (HPA)-1a antibodies affects primigravidas. Immunization must occur early in pregnancy before fetal platelets enter maternal blood via fetomaternal hemorrhage. The HPA-1a antigen is located on platelet glycoprotein (GP)IIIa (CD61, beta3 integrin), which is also present on the placental syncytiotrophoblast (ST) and in direct...
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