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Detection of Fetal DNA and RNA in Placenta-Derived Syncytiotrophoblast Microparticles Generated in Vitro

23 Oct 2004

Abstract excerpt

Fetal DNA and RNA can be readily detected in maternal plasma samples (1)(2)(3)(4). Most of this material appears to be of placental origin (5), and it appears to be in a predominantly cell-free form (2), whereas circulatory mRNA is membrane-encapsulated (6). Pregnancy is associated with the release of microparticles by the syncytiotrophoblast membrane into the maternal circulation (7). These particles,...

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PMID: 15502097
DOI: 10.1373/clinchem.2004.040196

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