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Article

Characterization of a phenylacetate-CoA ligase from Penicillium chrysogenum.

The Biochemical journal - 15 Jan 2009

Koetsier Martijn J, Jekel Peter A, van den Berg Marco A, Bovenberg Roel A L, Janssen Dick B

Abstract excerpt

Enzymatic activation of PAA (phenylacetic acid) to phenylacetyl-CoA is an important step in the biosynthesis of the beta-lactam antibiotic penicillin G by the fungus Penicillium chrysogenum. CoA esters of PAA and POA (phenoxyacetic acid) act as acyl donors in the exchange of the aminoadipyl side chain of isopenicillin N to produce penicillin G or penicillin V. The phl gene, encoding a PCL (phenylacetate-CoA...

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Identifiers

PMID: 18834333
DOI: 10.1042/BJ20081257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of a phenylacetate-CoA ligase from Penicillium chrysogenum.PMID 18834333Read ↗

Reprogramming Hansenula polymorpha for penicillin production: expression of the Penicillium chrysogenum pcl gene.Semantic proximity Read ↗

The global regulator LaeA controls penicillin biosynthesis, pigmentation and sporulation, but not roquefortine C synthesis in Penicillium chrysogenum.Semantic proximity Read ↗

Characterization of an acyl-CoA: carboxylate CoA-transferase from Aspergillus nidulans involved in propionyl-CoA detoxification.Semantic proximity Read ↗

Direct involvement of the CreA transcription factor in penicillin biosynthesis and expression of the pcbAB gene in Penicillium chrysogenum.Semantic proximity Read ↗

Molecular characterization of the phenylacetic acid catabolic pathway in Pseudomonas putida U: the phenylacetyl-CoA catabolon.Semantic proximity Read ↗

Mutational analysis of 4-coumarate:CoA ligase identifies functionally important amino acids and verifies its close relationship to other adenylate-forming enzymes.Semantic proximity Read ↗

Identification of a meta-cleavage pathway for metabolism of phenoxyacetic acid and phenol in Pseudomonas cepacia AC1100.Semantic proximity Read ↗

Characterization of the substrate specificity of PhlD, a type III polyketide synthase from Pseudomonas fluorescens.Semantic proximity Read ↗

Characterization of PhlG, a hydrolase that specifically degrades the antifungal compound 2,4-diacetylphloroglucinol in the biocontrol agent Pseudomonas fluorescens CHA0.Semantic proximity Read ↗

Phenylacetyl-CoA, not phenylacetic acid, attenuates CepIR-regulated virulence in <i>Burkholderia cenocepacia</i>Semantic proximity Read ↗

Genes for chlorogenate and hydroxycinnamate catabolism (hca) are linked to functionally related genes in the dca-pca-qui-pob-hca chromosomal cluster of Acinetobacter sp. strain ADP1.Semantic proximity Read ↗

Disruption of phacA, an Aspergillus nidulans gene encoding a novel cytochrome P450 monooxygenase catalyzing phenylacetate 2-hydroxylation, results in penicillin overproduction.Semantic proximity Read ↗

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