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Article

Reduced toll-like receptor 4 expression in children with asymptomatic bacteriuria.

The Journal of infectious diseases - 1 Aug 2007

Ragnarsdóttir Bryndís, Samuelsson Martin, Gustafsson Mattias C U, Leijonhufvud Irene, Karpman Diana, Svanborg Catharina

Abstract excerpt

Toll-like receptor (TLR) 4 is essential for the defense against infection with gram-negative pathogens, but reduced TLR4 expression has not been linked to altered disease susceptibility in humans. In mice, Tlr4 controls the mucosal response to Escherichia coli urinary tract infections. Inactivation of mouse Tlr4 causes an asymptomatic carrier state resembling asymptomatic bacteriuria (ABU). The present study...

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Source

Identifiers

PMID: 17597463
DOI: 10.1086/518893

Genes

TLR4
SIGIRR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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