Article
A dominant form of inherited retinal degeneration caused by a non-photoreceptor cell-specific mutation.
Proceedings of the National Academy of Sciences of the United States of America - 14 Oct 1997
Li L, Dowling J E
Abstract excerpt
We have isolated a dominant mutation, night blindness a (nba), that causes a slow retinal degeneration in zebrafish. Heterozygous nba fish have normal vision through 2-3 months of age but subsequently become night blind. By 9.5 months of age, visual sensitivity of affected fish may be decreased more than two log units, or 100-fold, as measured behaviorally. Electroretinographic (ERG) thresholds of mutant fish are...
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