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A Dysfunctional Tricarboxylic Acid Cycle Enhances Fitness of Staphylococcus epidermidis During β-Lactam Stress

21 Aug 2013

Abstract excerpt

UNLABELLED: A recent controversial hypothesis suggested that the bactericidal action of antibiotics is due to the generation of endogenous reactive oxygen species (ROS), a process requiring the citric acid cycle (tricarboxylic acid [TCA] cycle). To test this hypothesis, we assessed the ability of oxacillin to induce ROS production and cell death in Staphylococcus epidermidis strain 1457 and an isogenic citric...

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Share to Antibiotic Resistance in Bacteria
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23963176
DOI: 10.1128/mbio.00437-13

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