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Article

Autoubiquitination of BCA2 RING E3 ligase regulates its own stability and affects cell migration.

Molecular cancer research : MCR - 1 Sept 2008

Amemiya Yutaka, Azmi Peter, Seth Arun

Abstract excerpt

Accumulating evidence suggests that ubiquitination plays a role in cancer by changing the function of key cellular proteins. Previously, we isolated BCA2 gene from a library enriched for breast tumor mRNAs. The BCA2 protein is a RING-type E3 ubiquitin ligase and is overexpressed in human breast tumors. In order to deduce the biochemical and biological function of BCA2, we searched for BCA2-binding partners using...

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Identifiers

PMID: 18819927
DOI: 10.1158/1541-7786.MCR-08-0094
PMCID: PMC2814348

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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