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Article

Association of human aryl hydrocarbon receptor gene polymorphisms with risk of lung cancer among cigarette smokers in a Chinese population.

Pharmacogenetics and genomics - 1 Jan 2009

Chen Dan, Tian Tian, Wang Haifeng, Liu Hongliang, Hu Zhibin, Wang Yi, Liu Yanhong, Ma Hongxia, Fan Weiwei, Miao Ruifen, Sun Weiwei, Wang Yi, Qian Ji, Jin Li, Wei Qingyi, Shen Hongbing, Huang Wei, Lu Daru

Abstract excerpt

BACKGROUND AND OBJECTIVE: Most of the carcinogenic effects of polycyclic aromatic hydrocarbons present in tobacco smoke are mediated by the aryl hydrocarbon receptor (AHR), a ligand-dependent transcription factor that regulates tobacco-induced expression of carcinogen metabolic enzymes. We hypothesized that genetic variations in AHR might confer individual susceptibility to lung cancer. METHODS: Eight selected...

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Source

Identifiers

PMID: 18818557
DOI: 10.1097/FPC.0b013e328316d8d8

Genes

AHR

Variants

rs2066853

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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