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Article

Drosophila spalt/spalt-related mutants exhibit Townes-Brocks' syndrome phenotypes.

Proceedings of the National Academy of Sciences of the United States of America - 2 Sept 2003

Dong P D Si, Todi Sokol V, Eberl Daniel F, Boekhoff-Falk Grace

Abstract excerpt

Mutations in SALL1, the human homolog of the Drosophila spalt gene, result in Townes-Brocks' syndrome, which is characterized by hand/foot, anogenital, renal, and ear anomalies, including sensorineural deafness. spalt genes encode zinc finger transcription factors that are found in animals as diverse as worms, insects, and vertebrates. Here, we examine the effect of losing both of the spalt genes, spalt and...

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Source

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Identifiers

PMID: 12925729
DOI: 10.1073/pnas.1836391100
PMCID: PMC193554

Genes

SALL1

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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