Article
Japanese population structure, based on SNP genotypes from 7003 individuals compared to other ethnic groups: effects on population-based association studies.
American journal of human genetics - 1 Oct 2008
Yamaguchi-Kabata Yumi, Nakazono Kazuyuki, Takahashi Atsushi, Saito Susumu, Hosono Naoya, Kubo Michiaki, Nakamura Yusuke, Kamatani Naoyuki
Abstract excerpt
Because population stratification can cause spurious associations in case-control studies, understanding the population structure is important. Here, we examined Japanese population structure by "Eigenanalysis," using the genotypes for 140,387 SNPs in 7003 Japanese individuals, along with 60 European, 60 African, and 90 East-Asian individuals, in the HapMap project. Most Japanese individuals fell into two main...
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