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Article

Fgf16 is required for cardiomyocyte proliferation in the mouse embryonic heart

24 Sept 2008

Abstract excerpt

Fibroblast growth factor (Fgf) signaling plays important roles in development and metabolism. Mouse Fgf16 was predominantly expressed in cardiomyocytes. To elucidate the physiological roles of Fgf16, we generated Fgf16 knockout mice. Although the mice were apparently normal and fertile, heart weight and cardiomyocyte cell numbers were slightly decreased at 6 months of age. However, blood pressure, heart rate, and...

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PMID: 18816849
DOI: 10.1002/dvdy.21726

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