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Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP <sup>+</sup> , or paraquat

23 Sept 2008

Abstract excerpt

Inhibition of mitochondrial complex I is one of the leading hypotheses for dopaminergic neuron death associated with Parkinson's disease (PD). To test this hypothesis genetically, we used a mouse strain lacking functional Ndufs4, a gene encoding a subunit required for complete assembly and function of complex I. Deletion of the Ndufs4 gene abolished complex I activity in midbrain mesencephalic neurons cultured...

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PMID: 18812510
DOI: 10.1073/pnas.0807581105

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