Article
An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population.
Nagoya journal of medical science - 1 Mar 2008
Ji Xiaofei, Takahashi Nagahide, Branko Aleksic, Ishihara Ryoko, Nagai Taku, Mouri Akihiro, Saito Shinichi, Maeno Nobuhisa, Inada Toshiya, Ozaki Norio
Abstract excerpt
Genetic factors are thought to be involved in the development of treatment-resistant schizophrenia (TRS). Since several antipsychotic drugs inhibit the release of neurotransmitters via the serotonin receptors 3 (5-HT3), a dysfunction of this kind of receptor might be associated with the development of TRS. Thus, single-marker and haplotype analyses of the tag-single nucleotide polymorphisms (SNPs) of the 5-HT3B...
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