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Article

Clinical and molecular predictors of thrombocytopenia and risk of bleeding in patients with von Willebrand disease type 2B: a cohort study of 67 patients.

Blood - 15 Jan 2009

Federici Augusto B, Mannucci Pier M, Castaman Giancarlo, Baronciani Luciano, Bucciarelli Paolo, Canciani Maria T, Pecci Alessandro, Lenting Peter J, De Groot Philip G

Abstract excerpt

Type 2B von Willebrand disease (VWD2B) is caused by an abnormal von Willebrand factor (VWF) with increased affinity for the platelet receptor glycoprotein Ib-alpha (GPIb-alpha) that may result in moderate to severe thrombocytopenia. We evaluated the prevalence and clinical and molecular predictors of thrombocytopenia in a cohort of 67 VWD2B patients from 38 unrelated families characterized by VWF mutations....

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Source

Identifiers

PMID: 18805962
DOI: 10.1182/blood-2008-04-152280

Genes

VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Clinical and molecular predictors of thrombocytopenia and risk of bleeding in patients with von Willebrand disease type 2B: a cohort study of 67 patients.PMID 18805962Read ↗

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