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Growth of White Matter in the Adolescent Brain: Role of Testosterone and Androgen Receptor

17 Sept 2008

Abstract excerpt

The growth of white matter during human adolescence shows a striking sexual dimorphism; the volume of white matter increases with age slightly in girls and steeply in boys. Here, we provide evidence supporting the role of androgen receptor (AR) in mediating the effect of testosterone on white matter. In a large sample of typically developing adolescents (n = 408, 204 males), we used magnetic resonance imaging and...

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PMID: 18799683
DOI: 10.1523/jneurosci.1212-08.2008

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