Article
The difficult case of crystallization and structure solution for the ParC55 breakage-reunion domain of topoisomerase IV from Streptococcus pneumoniae.
PloS one - 12 Sept 2008
Sohi Maninder K, Veselkov Dennis A, Laponogov Ivan, Pan Xiao-Su, Fisher L Mark, Sanderson Mark R
Abstract excerpt
BACKGROUND: Streptococcus pneumoniae is the major cause of community-acquired pneumonia and is also associated with bronchitis, meningitis, otitis and sinusitis. The emergence and increasing prevalence of resistance to penicillin and other antibiotics has led to interest in other anti-pneumonococcal drugs such as quinolones that target the enzymes DNA gyrase and topoisomerase IV. During crystallization and in the...
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