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Article

Eccentric contractions do not induce rhabdomyolysis in malignant hyperthermia susceptible mice.

Journal of applied physiology (Bethesda, Md. : 1985) - 1 Nov 2008

Corona Benjamin T, Rouviere Clement, Hamilton Susan L, Ingalls Christopher P

Abstract excerpt

Recent studies suggest a link between exercise-induced rhabdomyolysis and mutations of the ryanodine receptor (RYR1) associated with malignant hyperthermia (MH). We hypothesized that MH-susceptible mice (RYR1Y522S/wt) would exhibit greater anterior crural muscle [tibialis anterior (TA) and extensor digitorum longus (EDL) muscles] damage and strength deficits following the performance of a single or repeated bouts...

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Identifiers

PMID: 18787086
DOI: 10.1152/japplphysiol.90926.2008
PMCID: PMC2584836

Genes

RYR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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