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Article

RecA433 cells are defective in recF-mediated processing of disrupted replication forks but retain recBCD-mediated functions.

Mutation research - 14 Oct 2008

Al-Hadid Qais, Ona Katherine, Courcelle Charmain T, Courcelle Justin

Abstract excerpt

RecA is required for recombinational processes and cell survival following UV-induced DNA damage. recA433 is a historically important mutant allele that contains a single amino acid substitution (R243H). This mutation separates the recombination and survival functions of RecA. recA433 mutants remain proficient in recombination as measured by conjugation or transduction, but are hypersensitive to UV-induced DNA...

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PMID: 18782580
DOI: 10.1016/j.mrfmmm.2008.08.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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RecA433 cells are defective in recF-mediated processing of disrupted replication forks but retain recBCD-mediated functions.PMID 18782580Read ↗

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Novel mechanism for UV sensitivity and apparent UV nonmutability of recA432 mutants: persistent LexA cleavage following SOS induction.Semantic proximity Read ↗

The mutant RecA proteins, RecAR243Q and RecAK245N, exhibit defective DNA binding in homologous pairing.Semantic proximity Read ↗

Analysis of recA mutants with altered SOS functions.Semantic proximity Read ↗

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Characterization of RecA1332 in vivo and in vitro. A role for alpha-helix E as a liaison between the subunit-subunit interface and the DNA and ATP binding domains of RecA protein.Semantic proximity Read ↗

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RecO acts with RecF and RecR to protect and maintain replication forks blocked by UV-induced DNA damage in Escherichia coli.Semantic proximity Read ↗

Properties of recA441 protein-catalyzed DNA strand exchange can be attributed to an enhanced ability to compete with SSB protein.Semantic proximity Read ↗

RecQ promotes toxic recombination in cells lacking recombination intermediate-removal proteins.Semantic proximity Read ↗

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