Article
Annexin A5 increases the cell surface expression and the chloride channel function of the DeltaF508-cystic fibrosis transmembrane regulator.
Biochimica et biophysica acta - 1 Oct 2008
Le Drévo Marie-Anne, Benz Nathalie, Kerbiriou Mathieu, Giroux-Metges Marie-Agnès, Pennec Jean-Pierre, Trouvé Pascal, Férec Claude
Abstract excerpt
Cystic fibrosis (CF) is caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. In CF, the most common mutant DeltaF508-CFTR is misfolded, is retained in the ER and is rapidly degraded. If conditions could allow DeltaF508-CFTR to reach and to stabilize in the plasma membrane, it could partially correct the CF defect. We have previously shown that annexin V (anxA5) binds to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.