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[Molecular mechanisms of protein C deficiency caused by C64W and F139V mutations].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 1 Mar 2007

Zhou Rong-Fu, Cai Xiao-Hong, Xie Shuang, Wang Wen-Bin, Dai Jing, Ding Qiu-Lan, Fang Yi, Xie Fei, Wang Xue-Feng, Wang Hongli

Abstract excerpt

OBJECTIVE: To study the molecular mechanisms of protein C (PC) deficiency caused by PC gene mutations of C64W, F139V and K150 deletion (K150d). METHODS: Wild-type and mutant PC cDNA expression plasmids (PCwt, PC C64W, PC F139V, PC K150d) were constructed and transfected into COS-7 cells or CHO cells respectively for in vitro expression study and immunofluorescent assay. Fluorescent real-time PCR was used to...

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PMID: 17649706

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