Article
Human genetic diseases of proteolysis.
Human mutation - 1 Jan 1999
Kato G J
Abstract excerpt
Although in the past protein stability commonly has been considered an inherent property of a given protein, the truth is far more complex. Elaborate enzymatic systems exist in multiple intracellular compartments to hydrolyze proteins. These systems are capable of providing a sensitive mechanism to regulate protein expression, a mechanism that is complementary to the transcriptional and translational control...
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