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Article

Mannose trimming targets mutant alpha(2)-plasmin inhibitor for degradation by the proteasome.

The Journal of biological chemistry - 18 Feb 2000

Chung D H, Ohashi K, Watanabe M, Miyasaka N, Hirosawa S

Abstract excerpt

We have previously characterized the molecular and cellular mechanisms of alpha(2)-plasmin inhibitor (alpha(2)PI) deficiency. The mutant alpha(2)PI-Nara and alpha(2)PI-Okinawa proteins were found to be retained and degraded in cells stably expressing these mutant forms of alpha(2)PI. Degradation of the two mutant alpha(2)PI proteins, mediated by proteasomes, occurred after a lag time of 1.5 h during which glucose...

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PMID: 10671537
DOI: 10.1074/jbc.275.7.4981

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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