Article
Variant haplotypes at XRCC1 and risk of oral leukoplakia in HPV non-infected samples.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Feb 2009
Majumder Mousumi, Indra Dipanjana, Roy Puspita Das, Datta Sayantan, Ray Jay Gopal, Panda Chinmay K, Roy Bidyut
Abstract excerpt
BACKGROUND: One of the mechanisms in human papillomavirus (HPV)-related carcinogenesis is inhibition of DNA repair by HPV oncoprotein. In this study, we investigated whether polymorphisms at XRCC1, one of the DNA repair loci, could modulate the risk of tobacco-related leukoplakia and cancer in HPV-infected individuals. METHODS: Tissue DNA from 83 oral cancer, 91 leukoplakia and 100 healthy controls were screened...
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