Article
Sensory gating endophenotype based on its neural oscillatory pattern and heritability estimate.
Archives of general psychiatry - 1 Sept 2008
Hong L Elliot, Summerfelt Ann, Mitchell Braxton D, McMahon Robert P, Wonodi Ikwunga, Buchanan Robert W, Thaker Gunvant K
Abstract excerpt
CONTEXT: The auditory sensory gating deficit has been considered a leading endophenotype in schizophrenia. However, the commonly used index of sensory gating, P50, has low heritability in families of people with schizophrenia, raising questions about its utility in genetic studies. We hypothesized that the sensory gating deficit may occur in a specific neuronal oscillatory frequency that reflects the underlying...
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