Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probands.

doi:10.1016/j.biopsych.2008.06.018

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Article

Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probands.

Biological psychiatry - 15 Dec 2008

Turetsky Bruce I, Greenwood Tiffany A, Olincy Ann, Radant Allen D, Braff David L, Cadenhead Kristin S, Dobie Dorcas J, Freedman Robert, Green Michael F, Gur Raquel E, Gur Ruben C, Light Gregory A, Mintz James, Nuechterlein Keith H, Schork Nicholas J, Seidman Larry J, Siever Larry J, Silverman Jeremy M, Stone William S, Swerdlow Neal R, Tsuang Debby W, Tsuang Ming T, Calkins Monica E

Abstract excerpt

BACKGROUND: N100 evoked potential amplitude and gating abnormalities have been widely observed in schizophrenia patients. However, previous studies have been inconclusive as to whether similar deficits are present in unaffected family members. The Consortium on the Genetics of Schizophrenia (COGS) is a multisite National Institute of Mental Health (NIMH) initiative examining neurocognitive and neurophysiological...

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PMID: 18701089
DOI: 10.1016/j.biopsych.2008.06.018
PMCID: PMC2653714

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