Article
Impact of serotonin transporter and catechol-O-methyl transferase genes polymorphism on gastrointestinal dysfunction in Swedish and Japanese familial amyloidotic polyneuropathy patients.
Clinica chimica acta; international journal of clinical chemistry - 1 Dec 2008
Obayashi Konen, Olsson Malin, Anan Intissar, Ueda Mitsuharu, Nakamura Masaaki, Okamoto Sadahisa, Yamashita Taro, Miida Takashi, Ando Yukio, Suhr Ole B
Abstract excerpt
BACKGROUND: Differences in the gastrointestinal manifestations have emerged between Swedish and Japanese familial amyloidotic polyneuropathy amyloidogenic transthyretin Valine30Methionine (FAP ATTR Val30Met) patients. To elucidate the cause of the differences, we investigated the associations between serotonin transporter gene-linked polymorphic region (5-HTTLPR) and/or catechol-O-methyl transferase (COMT) gene...
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