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Article

FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome.

Human reproduction (Oxford, England) - 1 Dec 2008

Goodarzi M O, Maher J F, Cui J, Guo X, Taylor K D, Azziz R

Abstract excerpt

BACKGROUND: Human homologs (FEM1A, FEM1B, FEM1C) of nematode sex determination genes are candidate genes for polycystic ovary syndrome (PCOS). We previously identified a FEM1A mutation (H500Y) in a woman with PCOS; FEM1B has been implicated in insulin secretion. METHODS: Women with and without PCOS (287 cases, 187 controls) were genotyped for H500Y and six FEM1A single nucleotide polymorphisms (SNPs), five FEM1B...

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Source

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Identifiers

PMID: 18757445
DOI: 10.1093/humrep/den324
PMCID: PMC2583941

Genes

FEM1B
FEM1A
FEM1C

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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