Article
HLA-DQB1*02 dose effect on RIA anti-tissue transglutaminase autoantibody levels and clinicopathological expressivity of celiac disease.
Journal of pediatric gastroenterology and nutrition - 1 Sept 2008
Nenna Raffaella, Mora Barbara, Megiorni Francesca, Mazzilli Maria Cristina, Magliocca Fabio Massimo, Tiberti Claudio, Bonamico Margherita
Abstract excerpt
OBJECTIVES: Celiac disease is an autoimmune enteropathy caused by gluten ingestion in genetically susceptible individuals. Anti-transglutaminase autoantibody (tTGAb) assay is useful to detect candidates undergoing intestinal biopsy. Our aim was to investigate whether the DQB1*02 allele could influence tTGAb titers and the clinicopathological expressivity of the disease. METHODS: A total of 124 patients with...
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