Article
Targeting iron acquisition blocks infection with the fungal pathogens Aspergillus fumigatus and Fusarium oxysporum.
PLoS pathogens - 1 Jan 2013
Leal Sixto M, Roy Sanhita, Vareechon Chairut, Carrion Steven deJesus, Clark Heather, Lopez-Berges Manuel S, Di Pietro Antonio, diPietro Antonio, Schrettl Marcus, Beckmann Nicola, Redl Bernhard, Haas Hubertus, Pearlman Eric
Abstract excerpt
Filamentous fungi are an important cause of pulmonary and systemic morbidity and mortality, and also cause corneal blindness and visual impairment worldwide. Utilizing in vitro neutrophil killing assays and a model of fungal infection of the cornea, we demonstrated that Dectin-1 dependent IL-6 pr...
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