Article
Low prevalence of CDKN2A/ARF mutations among early-onset cancers of breast, pancreas and malignant melanoma in Poland.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) - 1 Oct 2008
Debniak Tadeusz, van de Wetering Thierry, Scott Rodney, Nagay Leszek, Cybulski Cezary, Górski Bohdan, Jakubowska Anna, Gronwald Jacek, Masojć Bartłomiej, Huzarski Tomasz, Byrski Tomasz, Nej-Wołosiak Katarzyna, Kładny Józef, Maleszka Romuald, Lubinski Jan
Abstract excerpt
In this report the contribution of CDKN2A/ARF germline mutations to early-onset cancers of the breast, pancreas and malignant melanoma was examined. We screened 66 women with breast cancer diagnosed at age 30 and below, 72 melanoma patients with the median age at diagnosis < or = 40 years and 51 pancreatic cancer patients diagnosed under the age of 50 years. In the total set of 189 patients we found a novel...
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