Article
Tuberculosis and chronic hepatitis B virus infection in Africans and variation in the vitamin D receptor gene.
The Journal of infectious diseases - 1 Mar 1999
Bellamy R, Ruwende C, Corrah T, McAdam K P, Thursz M, Whittle H C, Hill A V
Abstract excerpt
The active metabolite of vitamin D, 1,25 dihydroxyvitamin D3, is an important immunoregulatory hormone [1]. Its effects are exerted by interaction with the vitamin D receptor, which is present on human monocytes and activated T and B lymphocytes. Variation in the vitamin D receptor gene was typed...
Topics
- Adolescent
- Adult
- B-Lymphocytes
- Black People
- Case-Control Studies
- Gambia
- Genetic Predisposition to Disease
- Genetic Variation
- Genotype
- Hepatitis B, Chronic
- Homozygote
- Humans
- Malaria
- Male
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Receptors, Calcitriol
- Reference Values