Article
Response of feline immunodeficiency virus (FIV) to tipranavir may provide new clues for development of broad-based inhibitors of retroviral proteases acting on drug-resistant HIV-1.
Current HIV research - 1 Jun 2008
Norelli Sandro, El Daker Sary, D'Ostilio Daniela, Mele Federico, Mancini Fabiola, Taglia Fabiana, Ruggieri Anna, Ciccozzi Massimo, Cauda Roberto, Ciervo Alessandra, Barreca Maria L, Pistello Mauro, Bendinelli Mauro, Savarino Andrea
Abstract excerpt
The feline AIDS model for HIV-1 treatment failed in the 1990s, due to structural features resembling protease inhibitor (PI) resistant HIV-1 variants. Widespread drug-resistance to PIs now invokes the possibility of rescuing feline immunodeficiency virus (FIV) as a model for PI treatment. We here analyzed susceptibility of FIV to second generation PIs, lopinavir, atazanavir, and the structurally unrelated...
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