Article
Tipranavir: a ritonavir-boosted protease inhibitor.
Drugs - 1 Jan 2005
Croom Katherine F, Keam Susan J
Abstract excerpt
Tipranavir is a non-peptidic HIV-1 protease inhibitor. It binds strongly and selectively, has a favourable resistance profile, and is administered orally twice daily with a subtherapeutic dosage of ritonavir in a 'boosted' regimen (TPV/r) in order to increase its bioavailability. Analysis of clinical isolates from treatment-experienced patients identified the following tipranavir resistance-associated HIV...
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