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Microscopy Underestimates the Frequency of Plasmodium Falciparum Infection in Symptomatic Individuals in a Low Transmission Highland Area

1 Aug 2008

Abstract excerpt

In an area with unstable malaria transmission, detection of Plasmodium falciparum infection in 379 symptomatic individuals was assessed by microscopy and three polymerase chain reaction (PCR) methodologies. P. falciparum infection was detected in 25% of patients by microscopy, 37% by nested PCR, 41% by merozoite surface protein-2 (MSP-2) PCR, and 45% by a ligase detection reaction-fluorescent microsphere assay...

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PMID: 18689620
DOI: 10.4269/ajtmh.2008.79.173

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