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High-Throughput Ultrasensitive Molecular Techniques for Quantifying Low-Density Malaria Parasitemias

3 Jul 2014

Abstract excerpt

The epidemiology of malaria in "low-transmission" areas has been underestimated. Molecular detection methods have revealed higher prevalences of malaria than conventional microscopy or rapid diagnostic tests, but these typically evaluate finger-prick capillary blood samples (∼5 μl) and therefore cannot detect parasite densities of <200/ml. Their use underestimates true parasite carriage rates. To characterize the...

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PMID: 24989601
DOI: 10.1128/jcm.01057-14

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