In situ activation of syngeneic tumour-specific cytotoxic T lymphocytes: intra-pinna immunization followed by restimulation in the peritoneal cavity.

doi:10.1007/BF01756594

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Article

In situ activation of syngeneic tumour-specific cytotoxic T lymphocytes: intra-pinna immunization followed by restimulation in the peritoneal cavity.

Cancer immunology, immunotherapy : CII - 1 Jan 1991

Schirrmacher V, Leidig S, Griesbach A

Abstract excerpt

Tumour-specific cytotoxic T lymphocytes (CTL) are usually obtained after immunization in vivo and restimulation of immune cells in vitro. We here describe the generation of syngeneic tumour-specific CTL within no more than 9 days by priming and restimulation in vivo. This is achieved only if the correct sites are used both for primary immunization (ear pinna) and for restimulation (peritoneal cavity). The...

Topics

Animals
Antibody Formation
Cytotoxicity, Immunologic
Ear, External
Histocompatibility Antigens
Immunization
Immunization, Passive
Immunization, Secondary
Kinetics
Lymphocyte Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred DBA

Neoplasms, Experimental

Peritoneal Cavity

Phenotype

Spleen

T-Lymphocytes, Cytotoxic

Source

Open in PubMed Open full text

Identifiers

PMID: 1868488
DOI: 10.1007/BF01756594
PMCID: PMC11038519

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1868488-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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