Article
Very early viral kinetics on interferon treatment in chronic hepatitis C virus genotype 4 infection.
Antiviral therapy - 1 Jan 2008
Jessner Wolfgang, Gschwantler Michael, Formann Elisabeth, Gurguta Calin, Watkins-Riedel Thomas, Wrba Friedrich, Ferenci Peter
Abstract excerpt
BACKGROUND: Interferon (IFN)-resistant hepatitis C virus strains limit efficacy of antiviral combination therapy in patients infected with genotypes 1 and 4. A single test dose of IFN was useful to identify non-responders to IFN-alpha2b/ribavirin (RBV) or likely non-responders to pegylated (PEG)-IFN-alpha2a/RBV therapy in genotype 1 patients. Our aim was to investigate this approach in genotype 4 patients....
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