Article
Uricosuric action of losartan via the inhibition of urate transporter 1 (URAT 1) in hypertensive patients.
American journal of hypertension - 1 Oct 2008
Hamada Toshihiro, Ichida Kimiyoshi, Hosoyamada Makoto, Mizuta Einosuke, Yanagihara Kiyotaka, Sonoyama Kazuhiko, Sugihara Shinobu, Igawa Osamu, Hosoya Tatsuo, Ohtahara Akira, Shigamasa Chiaki, Yamamoto Yasutaka, Ninomiya Haruaki, Hisatome Ichiro
Abstract excerpt
BACKGROUND: The angiotensin receptor blocker losartan inhibited urate transporter 1 (URAT1) according to in vitro experiments. However, it is still unknown whether the inhibitory effect of losartan on URAT1 contributes to its uricosuric action in humans. METHODS: Thirty-two patients with hypertension and nine patients with idiopathic renal hypouricemia (five with and four without hypertension) were enrolled for...
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