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Article

URAT1 gene polymorphisms influence uricosuric action of losartan in hypertensive patients with hyperuricemia.

Pharmacogenomics - 1 Jul 2015

Sun Hong, Qu Qiang, Qu Jian, Lou Xiao-Ya, Peng Yan, Zeng Ying, Wang Guo

Abstract excerpt

AIMS: To explore the effect of urate transporter 1 (URAT1) polymorphisms on the hypertensive patients with hyperuricemia and the uricosuric action of losartan therapy among hypertensive patients with hyperuricemia. METHODS: 101 hypertensive patients with hyperuricemia were detected the genotypes of URAT1 rs1529909 and rs3825016 and undergo a 2-weeks following losartan treatment. Before and after treatment, serum...

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PMID: 26086348
DOI: 10.2217/pgs.15.52

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