Article
[The effect of glibenclamide on the spontaneous evolution of genetically determined diabetes mellitus in C57BL/KsJY db+/+db mice].
Farmakologiia i toksikologiia - 1 Jan 2000
Poltorak V V, Gladkikh A I, Blokh K O, Brindak O I, Berestovskaia E V, Tur M I
Abstract excerpt
The study was carried out on 25 mice of the mutant C57BL/KsJY line carrying the autosomal-recessive gene db (diabetes) in the homozygous state with basal normo- and hyperglycemia by the beginning of the treatment with glybenclamide (the latent and manifest stages of insulin-independent diabetes mellitus). It was found that long-term oral administration of the drug in the therapeutic dose (20 micrograms per mice a...
Topics
- Animals
- Autoantibodies
- Autoimmunity
- Blood Glucose
- DNA
- Diabetes Mellitus, Experimental
- Diabetes Mellitus, Type 2
- Disease Susceptibility
- Drug Evaluation, Preclinical
- Female