Article
Polymorphisms of the endothelin-1 gene associate with hypertension in patients with rheumatoid arthritis.
Endothelium : journal of endothelial cell research - 1 Jan 2000
Panoulas Vasileios F, Douglas Karen M J, Smith Jacqueline P, Taffé Patrick, Stavropoulos-Kalinoglou Antonios, Toms Tracey E, Elisaf Moses S, Nightingale Peter, Kitas George D
Abstract excerpt
Rheumatoid arthritis (RA) associates with excess cardiovascular (CV) morbidity and mortality. Hypertension, a highly prevalent entity in RA, has been associated with the endothelin-1 (ET-1) gene locus (EDN1) in some groups, such as Afro-Caribbean, the obese, and in low-renin states, but not in the general population as a whole. High levels of plasma ET-1 have been observed in RA. This study evaluated the...
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