Article
A common polymorphism in the renin angiotensin system is associated with differential outcome of antihypertensive pharmacotherapy prescribed to Brazilian older women.
Clinica chimica acta; international journal of clinical chemistry - 1 Oct 2008
Moraes Clayton F, Souza Elias R, Souza Vinícius C, Medeiros Eloá F F, Gonçalves Thiago F, Toledo Juliana O, Karnikowski Mauro, Gomes Lucy, Karnikowski Margô G O, Córdova Cláudio, Nóbrega Otávio T
Abstract excerpt
BACKGROUND: Since variations on the renin angiotensin (RA) system tend to exert effects on blood pressure, we investigated the association of the common ACE and AT1R polymorphisms with response to a multivariate pharmacotherapy. METHODS: This prospective study involved 169 hypertensive, community-dwelling older women. Genotypes were obtained by length analysis or direct sequencing of PCR products. Blood...
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