Article
Vitamin D receptor gene polymorphism is associated with reduced disability in multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Nov 2008
Mamutse G, Woolmore J, Pye E, Partridge J, Boggild M, Young C, Fryer A, Hoban P R, Rukin N, Alldersea J, Strange R C, Hawkins C P
Abstract excerpt
Ultraviolet radiation (UVR) may contribute to multiple sclerosis (MS) outcome by a mechanism involving vitamin D and the vitamin D receptor (VDR). In 512 patients with MS duration of 10 or more years, we studied the association of VDR single nucleotide polymorphisms (A/G(1229), C/G(3444), G/A(3944), CC(20965), CC(30056), F/f(30875), C/T(48200), T/t(65013)) with outcome or disability. ff(30875) frequency was lower...
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