Article
Huntington CAG repeat size does not modify onset age in familial Parkinson's disease: the GenePD study.
Movement disorders : official journal of the Movement Disorder Society - 15 Aug 2008
McNicoll Christopher F, Latourelle Jeanne C, MacDonald Marcy E, Lew Mark F, Suchowersky Oksana, Klein Christine, Golbe Lawrence I, Mark Margery H, Growdon John H, Wooten G Frederick, Watts Ray L, Guttman Mark, Racette Brad A, Perlmutter Joel S, Ahmed Anwar, Shill Holly A, Singer Carlos, Saint-Hilaire Marie H, Massood Tiffany, Huskey Karen W, DeStefano Anita L, Gillis Tammy, Mysore Jayalakshmi, Goldwurm Stefano, Pezzoli Gianni, Baker Kenneth B, Itin Ilia, Litvan Irene, Nicholson Garth, Corbett Alastair, Nance Martha, Drasby Edward, Isaacson Stuart, Burn David J, Chinnery Patrick F, Pramstaller Peter P, Al-Hinti Jomana, Moller Anette T, Ostergaard Karen, Sherman Scott J, Roxburgh Richard, Snow Barry, Slevin John T, Cambi Franca, Gusella James F, Myers Richard H
Abstract excerpt
The ATP/ADP ratio reflects mitochondrial function and has been reported to be influenced by the size of the Huntington disease gene (HD) repeat. Impaired mitochondrial function has long been implicated in the pathogenesis of Parkinson's disease (PD), and therefore, we evaluated the relationship of the HD CAG repeat size to PD onset age in a large sample of familial PD cases. PD affected siblings (n = 495), with...
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