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Article

Age of Onset of Huntington's Disease in Carriers of Reduced Penetrance Alleles.

Movement disorders : official journal of the Movement Disorder Society - 1 Dec 2021

McDonnell Erin I, Wang Yuanjia, Goldman Jill, Marder Karen

Abstract excerpt

BACKGROUND: Age of manifest Huntington's disease (HD) onset correlates with number of CAG repeats in the huntingtin gene. Little is known about onset with 36 to 39 repeats, the "reduced penetrance" (RP) range. OBJECTIVES: We provide allele-specific estimates of HD penetrance (diagnostic confidence level of 4) for RP allele carriers. METHODS: We analyzed 431 pre-manifest RP allele carriers from Enroll-HD, the...

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Source

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Identifiers

PMID: 34536046
DOI: 10.1002/mds.28789
PMCID: PMC8688195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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