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Article

Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes.

American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 Aug 2008

Liu Yongmei, Freedman Barry I, Burdon Kathryn P, Langefeld Carl D, Howard Timothy, Herrington David, Goff David C, Bowden Donald W, Wagenknecht Lynne E, Hedrick Catherine C, Rich Stephen S

Abstract excerpt

BACKGROUND: Glycemic exposure activates 12-lipoxygenase (12LO) expression and formation of arachidonic acid-derived products. These products can induce cell hypertrophy, cell proliferation, and extracellular matrix deposition, potentially leading to diabetic nephropathy. STUDY DESIGN: Cross-secti...

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Identifiers

PMID: 18640486
DOI: 10.1053/j.ajkd.2007.12.033
PMCID: PMC2585503

Genes

ACR
ALOX12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18640486-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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