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Article

Self-limited hyperexcitability: functional effect of a familial hemiplegic migraine mutation of the Nav1.1 (SCN1A) Na+ channel.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 16 Jul 2008

Cestèle Sandrine, Scalmani Paolo, Rusconi Raffaella, Terragni Benedetta, Franceschetti Silvana, Mantegazza Massimo

Abstract excerpt

Familial hemiplegic migraine (FHM) is an autosomal dominant inherited subtype of severe migraine with aura. Mutations causing FHM (type 3) have been identified in SCN1A, the gene encoding neuronal voltage-gated Na(v)1.1 Na(+) channel alpha subunit, but functional studies have been done using the cardiac Na(v)1.5 isoform, and the observed effects were similar to those of some epileptogenic mutations. We studied...

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Identifiers

PMID: 18632931
DOI: 10.1523/JNEUROSCI.4453-07.2008
PMCID: PMC2721955

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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