Article
No evidence that polymorphisms of the vanishing white matter disease genes are risk factors in multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Sept 2008
Pronk Jc, Scheper Gc, van Andel Rj, van Berkel Cgm, Polman Ch, Uitdehaag Bmj, van der Knaap Ms
Abstract excerpt
Febrile infections are known to cause exacerbations in the white matter disorders 'vanishing white matter' (VWM) and multiple sclerosis (MS). We hypothesized that polymorphisms in EIF2B1-5, the genes involved in VWM, might be risk factors for the development of MS or temperature sensitivity in patients with MS. We found no difference in the frequencies of 15 EIF2B1-5 variants between patients with MS and healthy...
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