Article
Arg113His mutation of vanishing white matter is not present in multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Apr 2007
Lucas M, Suarez R, Marcos A, Solano F, Venegas A, Garcia-Sanchez M I, Ortiz L, Izquierdo G
Abstract excerpt
Vanishing white matter (VWM) is a childhood leukoencephalopathy with central hypomyelination, white matter rarefaction, and cystic degeneration. Adult onset, variable phenotype, and high frequency characterize Arg113His mutation caused by G338A polymorphism associated with VWM. A patient with trauma-associated onset, and clinical features compatible with multiple sclerosis (MS), was homozygous for G338A mutation...
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