Article
Evaluation of clinical and laboratory findings with JAK2 V617F mutation as an independent variable in essential thrombocytosis.
Molecular biology reports - 1 Oct 2014
Cetin Güven, Ozkan Tuba, Turgut Seda, Ali Cikrikcioglu M, Cem Ar M, Ayer Mesut, Unlu Ayhan, Celik Sevda Rabia, Sekin Yahya, Karatoprak Cumali
Abstract excerpt
Essential thrombocythemia (ET) is an entity of classic Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), characterized by thrombocytosis with megakaryocytic hyperplasia and thrombocytes are increased with abnormal functions. Discovery of the protein tyrosine kinase JAK2 V617F allele contributed to better understanding of the pathogenetic mechanisms of MPNs. Acquired single point mutation in...
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